| 產(chǎn)品編號(hào) | bs-1451R-AP |
| 英文名稱 | Rabbit Anti-PAFAH/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的脂蛋白磷脂酶A2抗體 |
| 別 名 | Lp-PLA2; PLA2G7; PAFAH; lipoprotein-associated phospholipase A2; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; PAF 2-acylhydrolase; LDL-associated phospholipase A2; LDL-PLA(2); 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase; PAFA_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 心血管 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from humna PAFAH C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl -sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. Function: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Plasma. DISEASE: Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms. Note=The disease is caused by mutations affecting the gene represented in this entry. Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the AB hydrolase superfamily. Lipase family. Database links: Entrez Gene: 7941 Human Omim: 601690 Human SwissProt: Q13093 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脂蛋白相關(guān)磷脂A2（Lp-PLA2）也稱血漿血小板激活因子乙酰水解酶，是介導(dǎo)氧化低密度脂蛋白引起炎癥和動(dòng)脈粥樣硬化的一個(gè)關(guān)鍵性酶。 脂蛋白相關(guān)磷脂酶A2是磷脂酶A2超家族的一個(gè)成員,由成熟的巨噬細(xì)胞和淋巴細(xì)胞合成和分泌,主要與低密度脂蛋白結(jié)合,能水解低密度脂蛋白上的氧化卵磷脂,生成促炎物質(zhì)溶血卵磷脂和氧化型游離脂肪酸,促進(jìn)動(dòng)脈粥樣硬化形成,經(jīng)研究認(rèn)為：抑制脂蛋白相關(guān)磷脂酶A2活性可能有抗動(dòng)脈粥樣硬化的效應(yīng)。 |
