| 產(chǎn)品編號(hào) | bs-0064R-BF488 |
| 英文名稱(chēng) | Rabbit Anti-Neurokinin 1 Receptor/BF488 Conjugated antibody |
| 中文名稱(chēng) | BF488標(biāo)記的P物質(zhì)受體抗體 |
| 別 名 | Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 新陳代謝 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Guinea Pig, G) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPR |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Subunit: Interacts with ARRB1 Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 6869 Human Entrez Gene: 21336 Mouse Omim: 162323 Human SwissProt: P25103 Human SwissProt: P30548 Mouse Unigene: 633301 Human Unigene: 8055 Mouse Unigene: 89609 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 此抗體與大、小鼠、及豚鼠均有交叉反應(yīng)。P物質(zhì)是由11個(gè)氨基酸組成的多肽，主要分布于感覺(jué)神經(jīng)纖維、后根神經(jīng)節(jié)和脊髓后角，作為重要的神經(jīng)遞質(zhì)或調(diào)制因子參與傷害性刺激的傳遞，該遞質(zhì)與突觸后膜上P物質(zhì)受體結(jié)合，將痛沖動(dòng)傳入中樞，產(chǎn)生疼痛反應(yīng)。 P物質(zhì)與神經(jīng)源性炎癥、瘙癢及疼痛的產(chǎn)生有關(guān)，通過(guò)刺激肥大細(xì)胞釋放組織胺、緩激肽及前列腺素等致炎、致敏、致痛物質(zhì)，引起一系列病理反應(yīng)，P物質(zhì)除作為傷害性信息的信使外，本身又為炎癥介質(zhì)。 |
