| 產(chǎn)品編號 | bs-1326R-BF594 |
| 英文名稱 | Rabbit Anti-FGF10/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的成纖維細(xì)胞生長因子10抗體 |
| 別 名 | FGF 10; FGF-10; Fibroblast growth factor 10; Keratinocyte growth factor 2; KGF 2; BB213776; fd11d03; FGF10; FGF10_HUMAN; wu:fd11d03; zgc:109774. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGF10 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008] Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Subunit: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Subcellular Location: Secreted (Potential). DISEASE: Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections. Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. Similarity: Belongs to the heparin-binding growth factors family. Database links: Entrez Gene: 2255 Human Entrez Gene: 14165 Mouse Omim: 602115 Human SwissProt: O15520 Human SwissProt: O35565 Mouse Unigene: 664499 Human Unigene: 317323 Mouse Unigene: 44439 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FGF-10對于角質(zhì)形成細(xì)胞的異常增殖和分化異常可能有著重要的調(diào)節(jié)作用。有學(xué)者認(rèn)為；部分腫瘤、胚胎發(fā)育紊亂、生長發(fā)育障礙性疾病、炎癥及修復(fù)異常、免疫性疾病、血液病、HIV感染等都與FGF-10有關(guān)。 |
