| 產(chǎn)品編號 | bs-0271R-BF488 |
| 英文名稱 | Rabbit Anti-Cytomegalovirus pp65 /BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的巨細(xì)胞病毒PP65/CMV低基質(zhì)磷脂蛋白抗體 |
| 別 名 | PP65_HCMVM; PP65_HCMVA; 65 kDa lower matrix phosphoprotein; 65 kDa matrix phosphoprotein; 65 kDa phosphoprotein; CMV 65 kDa lower matrix phosphoprotein; CMV pp65; Cytomegalovirus 65 kDa lower matrix phosphoprotein; Cytomegalovirus pp65; HHV 5; PP65; Tegument protein pp65; Tegument protein UL83; UL83; HCMV PP65. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from PP65_HCMVM |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Cytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period. CMV viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. pp65 is a 65kD phosphorylated glycoprotein and is the most abundant of the late antigens. Function: Counteracts the host antiviral immune response by preventing IRF3 to enter the nucleus once activated and phosphorylated. Participates also in the transactivation of viral major imediate-early genes by recruiting host IFI16 to their promoters. Subunit: Interacts with host NCL/nucleolin. Interacts with host IFI16. Subcellular Location: Virion tegument (Potential). Host nucleus. Host cytoplasm. Note=As part of the incoming virion, pp65 is targeted to the nucleus immediately after infection. The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection. Thereafter, pp65 is probably exported and accumulates in the cytoplasm. Also found in dense bodies. Post-translational modifications: Phosphorylation may play a role in the localization of the protein. Similarity: Belongs to the herpesviridae pp65 family. Database links: Entrez Gene: 3077579 Human herpesvirus 5 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 細(xì)胞巨化病毒是一種皰疹病毒, 易引起先天性畸形，且患者在接受大量輸血和免疫抑制力治療時(shí)它是引起并發(fā)癥的主要生物因子。 巨細(xì)胞病毒是一種感染肺、腎、腸和其他器官的條件致病菌。該抗體識別分子量為52、65、72以及86kDa的立即早期非結(jié)構(gòu)抗原。該抗原在感染2小時(shí)后即可被檢測到。而感染96小時(shí)達(dá)到峰值，并持續(xù)整個(gè)CMV周期。 初期感染此病毒的孕婦中近一半會將此病傳播給她的胎兒，被傳染的胎兒長大后易智力低下，失明或耳聾。 |
